University of Cambridge > > MRC Biostatistics Unit Seminars > BSU Seminar: “Estimation in two-stage adaptive threshold enrichment clinical trials”

BSU Seminar: “Estimation in two-stage adaptive threshold enrichment clinical trials”

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Alison Quenault.

It is now widely acknowledged that a patient’s characteristics may predict how they respond to treatments. Consequently several clinical trials assess the treatment effect in the full population and in biomarker-defined subpopulations. If a biomarker is continuous, a two-stage adaptive threshold enrichment trial incorporates determining the best threshold for defining a subpopulation. Stage 1 data are used to perform an interim analysis to determine if the new treatment is promising in the full population or in a subpopulation defined by one of the candidate biomarker threshold values. In stage 2, recruitment is restricted to the promising subpopulation. In this talk I will describe how to obtain point estimators that adjust for subpopulation selection associated with including stage 1 data in the confirmatory analysis.

This talk is part of the MRC Biostatistics Unit Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity