From nuclear transfer to prospects for cell replacement therapy: The origins and future of pluripotency and cellular reprogramming

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• Professor Sir John Gurdon, The Gurdon Institute
• Friday 23 November 2018, 17:45-19:10
• Wolfson College - The Lee Hall.

If you have a question about this talk, please contact Dr Antonio M. M. Rodrigues.

Abstract—The different cell types that compose our bodies are remarkably stable. Hardly ever do we find skin cells in the brain or liver cells in the heart. In those very special cases where some regeneration can take place in vertebrates, there is little if any evidence for a switch in cell-type. Nevertheless, nuclear transfer, cell fusion, and induced pluripotency can result in pluripotent embryo cells being derived from specialized adult cells. The mechanisms by which nuclear reprogramming can occur in these cases is beginning to be understood. It may become possible for new, regenerated cell-types to be derived from adult cells and given back to a patient so that they receive new cells of their own genetic constitution, thereby avoiding the need for immunosuppression. The history of work in this area, and the prospects for cell replacement in the future will be discussed.

This talk is part of the Wolfson College Science Society series.

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