Interrogating T cell signalling and effector function in hypoxic environments

Add to your list(s) Download to your calendar using vCal

• Dr Sarah Ross; Cell Signalling and Immunology, School of Life Sciences, University of Dundee, Scotland
• Monday 05 February 2018, 13:00-14:00
• Babraham - The Cambridge Building; Kings Hedges Room.

If you have a question about this talk, please contact Bobbie Claxton.

If you would like to attend this seminar, please contact us to arrange site access

Effector CD8 Cytotoxic T lymphocytes (CTL) play a vital role in eliminating infected and diseased cells. Defining the signalling networks and molecular mechanisms that govern CD8 T cell differentiation and optimal effector function is key to understanding T cell pathologies and discovering new molecular targets and strategies for therapies. During an immune response, T cell behavior can be shaped by microenvironmental cues. Critically, CTL are confronted by low oxygen in both physiological and pathological immunological niches. I have been using biochemistry, single-cell approaches and quantitative mass spectrometry methodologies in order to dissect signalling pathways and identify molecules that control T cell differentiation and effector function. My research goal is to develop an understanding of how environmental oxygen levels regulate the function of effector CTL with the aim of developing a framework that will allow improved understanding of how hypoxia can shape T cell responses. This talk will discuss novel insights into signalling mechanisms and transcriptional regulators that link oxygen sensing to the control of CD8 + T cell differentiation and function.

This talk is part of the Babraham Seminar series.

This talk is included in these lists:

• Babraham - The Cambridge Building; Kings Hedges Room
• Babraham Seminar
• Graduate-Seminars
• se393's list

Note that ex-directory lists are not shown.