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CATEGORIES:Babraham Seminar
SUMMARY:Interrogating T cell signalling and effector funct
 ion in hypoxic environments - Dr Sarah Ross\; Cell
  Signalling and Immunology\, School of Life Scienc
 es\, University of Dundee\, Scotland
DTSTART;TZID=Europe/London:20180205T130000
DTEND;TZID=Europe/London:20180205T140000
UID:TALK98260AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/98260
DESCRIPTION:Effector CD8+ Cytotoxic T lymphocytes (CTL) play a
  vital role in eliminating infected and diseased c
 ells. Defining the signalling networks and molecul
 ar mechanisms that govern CD8+ T cell differentiat
 ion and optimal effector function is key to unders
 tanding T cell pathologies and discovering new mol
 ecular targets and strategies for therapies. Durin
 g an immune response\, T cell behavior can be shap
 ed by microenvironmental cues. Critically\, CTL ar
 e confronted by low oxygen in both physiological a
 nd pathological immunological niches. I have been 
 using biochemistry\, single-cell approaches and qu
 antitative mass spectrometry methodologies in orde
 r to dissect signalling pathways and identify mole
 cules that control T cell differentiation and effe
 ctor function. My research goal is to develop an u
 nderstanding of how environmental oxygen levels re
 gulate the function of effector CTL with the aim o
 f developing a framework that will allow improved 
 understanding of how hypoxia can shape T cell resp
 onses. This talk will discuss novel insights into 
 signalling mechanisms and transcriptional regulato
 rs that link oxygen sensing to the control of CD8+
  T cell differentiation and function.
LOCATION:Babraham - The Cambridge Building\; Kings Hedges R
 oom
CONTACT:Bobbie Claxton
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