Mitotic Chromosome Condensation and Segregation

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• Dr Frank Uhlmann, Cancer Research UK London Research Institute
• Tuesday 19 February 2008, 18:15-19:00
• Lecture Theatre, Department of Pathology.

If you have a question about this talk, please contact Dr. Walid Khaled.

Mitotic chromosome structure depends on the chromosomal condensin complex. Without condensin, metaphase chromosomes remain undercondensed and lack structural stability. This causes chromosome segregation defects during anaphase, resulting in aneuploidy as seen associated with most tumours. To understand the mechanism of chromosome condensation, we have asked where along budding yeast chromosomes the condensin complex associates, and what we can learn from its binding pattern. Our results suggest that condensin, like its relative the cohesin complex, is loaded onto chromosomes by a loading factor, the Scc2/4 complex. Unlike cohesin, that moves away from its loading sites after the loading reaction, condensin remains there in a dynamic equilibrium. The loading sites are characterised by the RNA polymerase III transcription factor TFIIIC . These findings have important implications for both interphase and mitotic chromosome structure.

This talk is part of the Cambridge Seminars in Disease Mechanisms series.

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