Can we predict the course of Crohn's disease?

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• Daniele Biasci
• Thursday 11 May 2017, 13:10-14:00
• The Richard King Room, Darwin College.

If you have a question about this talk, please contact KC Sivaramakrishnan.

Crohn’s disease (CD) is a chronic inflammatory condition affecting the gastrointestinal tract, thought to arise from a dysregulated interaction between the host immune system and the gut microbiota. Symptoms may be debilitating and usually require a lifetime of care.

Some patients experience frequent relapses and require treatment with increasingly potent immunosuppressants and/or surgery, whereas others achieve prolonged remission without any additional therapy. Such variability in prognosis occurs in other immune-mediated diseases and can make the difference between an excellent long-term outcome or progressive disability. Yet, the causes of such variation remain largely unknown.

The inability to predict disease course consequently affects clinicians and patients, leaving them with a choice between two unsatisfactory options: proactive treatments which may be unnecessary, or reactive therapies which may arrive too late. Solving this challenge would not only enable doctors to tailor treatment appropriately, but also help them design better treatments, which could specifically target the biological processes responsible for frequent disease flare ups.

This talk is part of the Darwin College Science Seminars series.

This talk is included in these lists:

• AUB_Cambridge Seminars
• All Talks (aka the CURE list)
• Centre for Health Leadership and Enterprise
• Chris Davis' list
• Darwin College Research Talks
• Darwin College Science Seminars
• Darwin Lectures and Seminars
• Guy Emerson's list
• Interested Talks
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• The Richard King Room, Darwin College
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