Spindle Orientation in Epithelial Cells

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• Dan Bergstralh, St Johnston lab
• Wednesday 28 October 2015, 17:30-19:30
• Gurdon Institute Tea Room.

If you have a question about this talk, please contact Clara Sidor.

The orientation in which a cell divides is determined by the angle of the mitotic spindle. Spindle orientation is well studied in asymmetrically-dividing cells, like Drosophila neuroblasts, which use oriented divisions to determine daughter cell fate. Less attention has been paid to the spindle orientation in symmetrically-dividing epithelial cells, which orient divisions to build and maintain epithelial sheets. My work in the St Johnston lab is focused on two questions: 1) How does spindle orientation work in these tissues? 2) What happens when it doesn’t?

This talk is part of the Cambridge Fly Meetings series.

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