University of Cambridge > Talks.cam > Darwin College Science Seminars > Spiking irregularity in cortical inhibitory interneurons

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Spiking irregularity in cortical inhibitory interneurons

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Aleksandr Sahakyan.

Excitatory Pyramidal Neurons (PN) are the main output source of the Neocortex. These cells are affected by the activity of Interneurons, which display a striking variety of morphologies, neuropeptides, and spiking patterns. The Irregular Spiking (IS) interneuron is of particular interest, displaying a dispersed spiking time when stimulated in vitro, even when synapses are blocked. It could be said that IS interneurons add randomness to the cortical network. The relevance of this irregularity is still unclear. This work aims to address the mechanism and function of this irregularity. We first recorded a population of rat cortical neurons and showed that IS cells only display abnormal interspike intervals (ISI) at frequencies below 15hz. Voltage clamp recordings of IS cells presented a prominent fast transient outward current that may be involved in this intrinsic irregularity. We are next addressing whether this irregularity is influenced by cell morphology via cell dissociation. Future prospects include morphological reconstruction and double whole-cell patch clamp to better understand how IS cells synchronise with each other.

This talk is part of the Darwin College Science Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

Cambridge University Linguistic Society (LingSoc) Henry Martyn Lectures Adams Society of St John's College PHG Foundation Combining chemical-genetic with metabolic profiling to study a dynamic metabolic transition Nineteenth-Century Epic

Other talks

Protein Folding, Evolution and Interactions Symposium Chemical genetic approaches to accelerate antimalarial target discovery Power to the People – Creating Markets for Supply Security Based on Consumer Choice Small Opuntioideae St Catharine’s Political Economy Seminar - ‘Bank Credit Rating Changes, Capital Structure Adjustments and Lending’ by Claudia Girardone Molecular mechanisms of cardiomyopathies in patients with severe non-ischemic heart failure Direct measurements of dynamic granular compaction at the mesoscale using synchrotron X-ray radiography Asclepiadaceae Sustainability of livestock production: water, welfare and woodland Acceleration of tropical cyclogenesis by self-aggregation feedbacks
 

© 2006-2024 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity