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Cancer Gene Discovery in the Mouse

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If you have a question about this talk, please contact Dr Ireena Dutta.

Hutchison/MRC Research Centre Seminar

Although we are large multi-cellular organisms with a long lifespan cancers form relatively rarely suggesting there are many growth controls checkpoints that restrain tumourigenesis. A corollary to this is that in most cancer types there are a limited number of genes that are frequently mutated but also many other genes that have been identified as potentially contributing to tumourigenesis. How these genes interact to drive tumour formation, the sequence of mutations required for tumour formation, and the complete repertoire of cancer driver genes is largely unknown. In this talk I will give several examples of how we are using the mouse to identify cancer driver genes and to understand how they interact in driving tumour formation.

This talk is part of the Cambridge Oncology Seminar Series series.

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