A short and personal history of planar cell polarity

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• Peter A. Lawrence - Department of Zoology
• Wednesday 02 April 2025, 16:00-17:30
• Max Perutz Lecture Theatre. LMB. Cambridge..

If you have a question about this talk, please contact Daniel Sobrido-Cameán.

Its about 30 years since we started to research planar cell polarity, a small defined field with its feet in genetics and its head in theory. How do cells orient themselves in the whole, how do they align the little structures such as subcellular denticles of insects or the multicellular hairs of a mammal, how do they know which way to send out an axon, which way to point a nascent arm? When we started the field was intriguing, fashionable. Now it remains important and interesting but is rusty and largely abandoned. Most scientists who worked in the field have moved on, leaving many problems unsolved. We (and others) used fly genetics. We summarise some principles of mechanism that we discovered with genetic mosaics.

This talk is part of the Cambridge Fly Meetings series.

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