Ageing without microbes – An old dialogue between microbes and mitochondria

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• Professor Filipe Cabreiro, University of Cologne, Germany
• Wednesday 15 October 2025, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Lisa Arnold.

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Prolongation of lifespan is one of the greatest achievements of modern medicine. As an unfortunate consequence, age-related diseases are thriving. A comprehensive understanding of the ageing process is therefore crucial for healthy ageing. While human host genetics are not straightforward to tinker with, diet and the microbiota are excellent untapped opportunities to improve disease states. Dysbiosis has been recently proposed as a hallmark of ageing through the development of a chronic low-grade inflammatory state, and may be one of the driving factors behind age-related diseases. Using model systems including germ-free and conventionally raised wildtype and mitochondrial deficient progeria mouse models, we investigate the role of gut microbiota in the development of age-related phenotypes to identify tissue cross-talk regulators modulated by the microbiota. The promising research endeavors in this area are the identification of early biomarkers and actionable mechanisms for improving healthy ageing.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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