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The microscopic barriers protecting your airway everyday

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Between the cells lining your airways are restrictive, protective and selective barriers called tight junctions. These tight junctions contribute to the first line of defence against inhaled viruses, toxicants and pollutants, and their disruption is implicated in many chronic respiratory diseases including asthma and COPD . My PhD seeks to use cutting-edge microscopy techniques to establish the structure of these barriers in the airway in health and in disease, and to identify the precise molecular mechanisms by which they can be damaged, which may reveal therapeutic avenues for their restoration.

This talk is part of the Darwin College Science Seminars series.

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