New mitochondrial mechanisms of degenerative diseases

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• Professor Anu Suomalainen
• Tuesday 03 December 2024, 16:00-17:00
• The Max Perutz Lecture Theatre, LMB.

If you have a question about this talk, please contact Lisa Arnold.

Mitochondrial diseases show unprecedented variability in different organ manifestations and ages of onset, but the mechanisms underlying such spectrum are poorly understood. Here, we report molecular mechanisms of how exogenous, actionable factors, or secondary metabolic pathway imbalance, have major effects on the disease course, both for disease onset and type of manifestation. For example, a specific recessively inherited mitochondrial disease allele in DNA polymerase gamma causes sensitivity to viral infections, allowing viral replication in early infection and causing a strong delayed proinflammatory response with dramatic effects on GABA -ergic neurons and liver homeostasis. Also, a muscle manifesting mitochondrial disease causes systemic NAD + deficiency – bodily B3 vitamin deficiency -the rescue of which has functional benefits. Targeting exogenous triggering factors or endogenous secondary metabolic consequences, based on mechanistic precision targets, are intriguing intervention strategies, with potential to delay disease-onset or restore functions.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC Mitochondrial Biology Unit Seminars
• The Max Perutz Lecture Theatre, LMB
• Trust & Technology Initiative - interesting events

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