Adding new dimensions to invitro models of stroke and cSVD

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• Dr Paul Holloway - University of Oxford
• Thursday 24 October 2024, 13:00-14:00
• VPD-HLRI, Cambridge Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB.

If you have a question about this talk, please contact Denise Hatherly.

Stroke is the largest cause of adult disability in the world and despite over 1000 prospective neuroprotective agents having been investigated pre-clinically, none have yet translated to the clinic. A number of key differences in the neurobiology of animal models and humans exist at both the cellular and molecular level, providing impetus to study human based systems. However, human in vitro stroke models are typically limited to simplistic monolayer cell cultures which fail to recapitulate the high level of structural organisation in the brain, 3D heterotypic cellular interactions and spatio-temporal localisation of injury. In his lab Dr Holloway is using a range of techniques from iPSC and organoid cultures to microfluidic systems, to model and investigate specific aspects of stroke injury. Dr Holloway’s talk will give an overview of how these different approaches can be used to model neuronal circuits and gliovascular interactions, along with examples of how these systems can provide novel insights into disease mechanisms and therapeutic opportunities.

This talk is part of the Cambridge Cardiovascular Seminar Series series.

This talk is included in these lists:

• Cambridge Cardiovascular Seminar Series
• Cardiovascular Epidemiology Unit Special Seminars
• VPD-HLRI, Cambridge Biomedical Campus, Papworth Road, Trumpington, Cambridge CB2 0BB
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