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CATEGORIES:Cambridge Cardiovascular Seminar Series
SUMMARY:Adding new dimensions to invitro models of stroke 
 and cSVD - Dr Paul Holloway - University of Oxford
DTSTART;TZID=Europe/London:20241024T130000
DTEND;TZID=Europe/London:20241024T140000
UID:TALK222298AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/222298
DESCRIPTION:Stroke is the largest cause of adult disability in
  the world and despite over 1000 prospective neuro
 protective agents having been investigated pre-cli
 nically\, none have yet translated to the clinic. 
 A number of key differences in the neurobiology of
  animal models and humans exist at both the cellul
 ar and molecular level\, providing impetus to stud
 y human based systems. However\, human in vitro st
 roke models are typically limited to simplistic mo
 nolayer cell cultures which fail to recapitulate t
 he high level of structural organisation in the br
 ain\,  3D heterotypic cellular interactions and sp
 atio-temporal localisation of injury. In his lab D
 r Holloway is using a range of techniques from iPS
 C and organoid cultures to microfluidic systems\, 
 to model and investigate specific aspects of strok
 e injury. Dr Holloway’s talk will give an overview
  of how these different approaches can be used to 
 model neuronal circuits and gliovascular interacti
 ons\, along with examples of how these systems can
  provide novel insights into disease mechanisms an
 d therapeutic opportunities.
LOCATION:VPD-HLRI\, Cambridge Biomedical Campus\, Papworth 
 Road\, Trumpington\, Cambridge CB2 0BB
CONTACT:Denise Hatherly
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