T cell responses to EBV: viral evasion, antigen immunodominance and priming

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• Professor Alan Rickinson, University of Birmingham
• Wednesday 03 February 2010, 12:30-13:30
• Lecture Theatre, Department of Pathology, Tennis Court Road.

If you have a question about this talk, please contact Prof. Jim Kaufman.

Host: Jim Kaufman (jfk31@cam.ac.uk)

Our work focuses on Epstein-Barr virus (EBV), a human gamma-herpesvirus with B cell growth-transforming ability that is the causative agent of a self-limiting lymphoproliferative disease, infectious mononucleosis, and is aetiologically linked to a range of lymphoid and epithelial malignancies.

Besides studying these disease associations, our more basic interests include the mechanisms of EBV persistence and immune evasion in the immune host. The seminar will cover the basic immunology of EBV infection, including recent work on antigen choice for CD4 and CD8 T cell responses and the effect of immune evasion on that choice.

This talk is part of the Immunology in Pathology series.

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