Non-uniform regulation of epigenetic marks via metabolism in a developing tissue

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• Professor Dr Aurelio Teleman
• Wednesday 08 May 2024, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Lisa Arnold.

Histone acetylation regulates gene expression, cell function, and cell fate. We studied the pattern of histone acetylation in an epithelial tissue, the Drosophila wing disc and find that H3K18ac, H4K8ac, and total lysine acetylation are elevated in the outer rim of the disc. This is due in part to high fatty acid β-oxidation (FABO) in the rim, and partly due to nuclear positioning. This affects gene expression. In sum, there is a physical mark of the outer rim of the wing and other epithelia in Drosophila.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

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• All Talks (aka the CURE list)
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• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
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