Targeting liver mitochondria to treat MASLD/MASH and cardiometabolic disease

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• Professor Gerald Shulman
• Wednesday 20 March 2024, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Lisa Arnold.

Insulin resistance is a critical factor in the pathogenesis of type 2 diabetes. In addition insulin resistance plays a key role in the pathogenesis of MASLD /MASH, heart disease, obesity-associated cancers and Alzheimer’s disease. In this lecture I will review recent studies that have demonstrated the safety and efficacy of liver-targeted mitochondrial uncoupling agents to treat these diseases in both animal models and humans with MASLD /MASH and cardiometabolic disease. I will also review some novel 13C NMR and LC-MS/MS methods (PINTA and Q-Flux) that we have recently developed to assess rates of hepatic mitochondrial oxidation and anaplerotic fluxes in vivo.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
• Trust & Technology Initiative - interesting events

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