The Wonders of Small Molecule Transport

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• Professor David Drew | Stockholm University
• Wednesday 15 February 2023, 15:00-16:00
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY.

If you have a question about this talk, please contact Hannah Burns.

Solute Carrier (SLC) transporters mediate the translocation of substrates across membranes and after GPC Rs represent the second-largest fraction of the human membrane proteome. SLC transporters are critical to cell homeostasis, which is reflected in the fact that more than a quarter of them are associated with Mendelian disease. Despite a few exceptions, however, they have been under-utilized as drug targets and our mechanistic understanding has been hampered due to technical difficulties in working with them. Here, I will present our multidisciplinary approach that has revealed important insights into the mechanism of SLC2 (GLUT) and SLC9 (Na+/H+ exchanger) transporter families that are important for our cells to utilize glucose as an energy source, and for the regulation cytoplasmic and organellar pH. I will also present our most recent biochemical and structural insights into ADP /ATP exchanger belonging to the SLC35 (nucleotide-sugar) family, which is essential for the uptake of ATP into ER and Golgi organelles for a number of biological processes, such as protein-folding.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• CamBridgeSens
• Cambridge talks
• Life Science Interface Seminars
• MRC MBU, Level 7 Lecture Theatre, The Keith Peters Building, CB2 0XY
• MRC Mitochondrial Biology Unit Seminars
• Trust & Technology Initiative - interesting events

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