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University of Cambridge > Talks.cam > DAMTP Statistical Physics and Soft Matter Seminar > The dopamine circuit as a reward-taxis navigation system

## The dopamine circuit as a reward-taxis navigation systemAdd to your list(s) Download to your calendar using vCal - Omer Karin, Imperial College London
- Tuesday 11 October 2022, 13:00-14:00
- Center for Mathematical Sciences, Lecture room MR4.
If you have a question about this talk, please contact Camille Scalliet. Studying the brain circuits that control behavior is challenging, since in addition to their structural complexity there are continuous feedback interactions between actions and sensed inputs from the environment. It is therefore important to identify mathematical principles that can be used to develop testable hypotheses. In this study, we use ideas and concepts from systems biology to study the dopamine system, which controls learning, motivation, and movement. Using data from neuronal recordings in behavioral experiments, we developed a mathematical model for dopamine responses and the effect of dopamine on movement. We show that the dopamine system shares core functional analogies with bacterial chemotaxis. Just as chemotaxis robustly climbs chemical attractant gradients, the dopamine circuit performs ‘reward-taxis’ where the attractant is the expected value of reward. The reward-taxis mechanism provides a simple explanation for scale-invariant dopaminergic responses and for matching in free operant settings, and makes testable quantitative predictions. We propose that reward-taxis is a simple and robust navigation strategy that complements other, more goal-directed navigation mechanisms. This talk is part of the DAMTP Statistical Physics and Soft Matter Seminar series. ## This talk is included in these lists:- All CMS events
- Center for Mathematical Sciences, Lecture room MR4
- DAMTP Statistical Physics and Soft Matter Seminar
- Soft Matter
- bld31
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