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Functional redundancy of Drosophila melanogaster SoxB proteins in central nervous system development

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During neural development, SoxB proteins are transcriptions factors that play an important role in the maintenance of stem-cell identity. One member of this family, Sox2 has been successfully used to induce cells into a pluripotent state (iPSCs) and is involved in different disorders promoting cells self-renewal. Interestingly, SoxB proteins have shown pioneer and redundant activity even when natural selection imposes evolutionary pressure to prevent gene duplications. Moreover, a high functional conservation and high levels of sequence similarity, allow us to assess functionality in vivo and at a chromatin level using Drosophila melanogaster as our model organism and its genes SoxN and Dichaete, orthologs of mammalian and other vertebrates SoxB genes

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