University of Cambridge > > Morphogenesis Seminar Series > From cell dynamics to robust tissue folding

From cell dynamics to robust tissue folding

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  • UserMagali Suzanne World_link
  • ClockMonday 01 February 2021, 14:30-15:30
  • HouseOnline.

If you have a question about this talk, please contact ucam-morphogenesis-committee.

Mechanical forces are critical regulators of cell shape changes and tissue remodelling during developmental morphogenetic processes. Recently, we revealed that apoptotic cells, far from being eliminated passively, are generating apico-basal forces that constitute an important mechanical signal involved in epithelial folding in the developing leg of Drosophila. Here, I will present more recent works, based on this initial discovery regarding the cellular mechanism responsible for force generation in apoptotic cells and the potential conservation of this mechanism in vertebrate. I will further discuss the surprising similarities of the mechanical impact of apoptotic cells to the one of ingressing cells undergoing EMT on tissue remodelling. Finally, I will present data regarding the mechanics of morphogenesis robustness involving Myosin II planar polarity and the Arp2/3 complex.

This talk is part of the Morphogenesis Seminar Series series.

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