![]() |
COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. | ![]() |
University of Cambridge > Talks.cam > All Talks (aka the CURE list) > Cohesins Functionally Associate with CTCF on Mammalian Chromosome Arms
Cohesins Functionally Associate with CTCF on Mammalian Chromosome ArmsAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Duncan Simpson. Cohesins mediate sister chromatid cohesion, which is essential for chromosome segregation and postreplicative DNA repair. In addition, cohesins appear to regulate gene expression and enhancer-promoter interactions. These noncanonical functions remained unexplained because knowledge of cohesin-binding sites and functional interactors in metazoans was lacking. We show that the distribution of cohesins on mammalian chromosome arms is not driven by transcriptional activity. Instead, mammalian cohesins occupy a subset of DNase I hypersensitive sites, many of which contain sequence motifs resembling the consensus for CTCF , a DNA -binding protein with enhancer blocking function and boundary element activity. We find cohesins at most CTCF sites and show that CTCF is required for cohesin localization to these sites. Recruitment by CTCF suggests a rationale for noncanonical cohesin functions and, because CTCF binding is sensitive to DNA methylation, allows cohesin positioning to integrate DNA sequnce and epigenetic state. This talk is part of the All Talks (aka the CURE list) series. This talk is included in these lists:
Note that ex-directory lists are not shown. |
Other listsLarmor Society 2009 IfM Research Capability Development Programme Seminar Series Women@CL EventsOther talksReplication or exploration? Sequential design for stochastic simulation experiments Panel comparisons: Challenor, Ginsbourger, Nobile, Teckentrup and Beck Adrian Seminar: Ensemble coding in amygdala circuits CANCELLED: The rise and fall of the Shopping Mall: dialogues on the relationship of commerce and city Repetitive Behavior and Restricted Interests: Developmental, Genetic, and Neural Correlates |