University of Cambridge > > MRC Mitochondrial Biology Unit Seminars > Mitochondrial dynamics in muscle physiopathology

Mitochondrial dynamics in muscle physiopathology

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Hannah Burns.

Mitochondrial quality control is essential in highly structured cells such as neurons and muscles. In skeletal muscle the mitochondrial shaping machinery and mitophagy are altered in different physiopathological conditions that are characterized by muscle loss and weakness. The abnormal mitochondria signal to the nucleus to induce several signaling pathways that control proteostasis, inflammatory response and senescence. Importantly, the shape of the mitochondrial network more than mitochondrial function is an important factor for the activation of specific pathways that control peculiar phenotypes. Fusion defect triggers sarcopenia and systemic ageing while fission impairment causes myopathy. Here, I will present the latest data that connect mitochondrial network to signaling pathways that controls muscle mass.

This talk is part of the MRC Mitochondrial Biology Unit Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2024, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity