Bordetella autotransporters: virulence factors, vaccine candidates and models for unraveling type V secretion mechanisms

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• Dr Rachel Fernandez, University of British Columbia, Vancouver, Canada
• Monday 07 April 2008, 13:00-14:00
• Lecture Theatre 2, Department of Veterinary Medicine.

If you have a question about this talk, please contact Duncan Maskell.

Autotransporters are a major class of outer membrane proteins in Gram-negative bacteria. They function as virulence factors (e.g. adhesins and proteases), are implicated in biofilm formation, and have been used to bioengineer heterologous functional modules on bacterial surfaces. Autotransporters also provide a model to examine fundamental biological questions of how proteins cross membranes. There are ~ 30 autotransporters present in Bordetella bronchiseptica, B. pertussis, B. parapertussis and B. avium.

In this seminar I will provide an overview of the Bordetella autotransporters, dissect the secretion of the B. pertussis BrkA autotransporter, and discuss the protective capacity of BrkA in the murine lung colonization model.

This talk is part of the Special Veterinary Medicine Seminars series.

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