Identifying genes involved in sense organ formation in Drosophila

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• Sebastian Cachero, Division of Biomedical Sciences, University of Edinburgh
• Tuesday 05 February 2008, 16:00-16:45
• MRC LMB: Neurobiology Division Seminar Room (Level 2).

If you have a question about this talk, please contact Gregory Jefferis.

Proneural proteins are transcription factors that occupy the highest position in the genetic network that drives sense organ formation. One of the central questions in the field is how the identity of the proneural protein is linked to aspects of terminal differentiation. In order to address this issue, a method combining fluorescent activated cell sorting and gene expression microarrays was developed and used to identify the transcriptional profiles of sense organ precursors and their progeny. Interestingly, among the genes we identified there is a group of differentiation genes, raising the possibility that proneural proteins directly control aspects of terminal differentiation. Another finding was the possible involvement in sense organ formation of a microRNA gene.

This talk is part of the MRC LMB Neurobiology Seminars series.

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