Antibiotic resistance: The search for novel Lipoteichoic acid Synthase inhibitors

Add to your list(s) Download to your calendar using vCal

• Mr Rohan Eapen, Department of Pharmacology, University of Cambridge
• Thursday 01 March 2018, 13:10-14:00
• The Richard King Room, Darwin College.

If you have a question about this talk, please contact Lorena Escudero.

In 1928, Alexander Fleming famously discovered what was to be the ‘miracle drug’, penicillin. Fast forward 90 years to the present day, we still find penicillin and its derivatives widely used in the clinic today. However, one major problem that is beginning to come to light is the widespread emergence of antibiotic resistance. As such, the World Health Organistation have declared research into novel antibiotics and diagnostic tools of paramount importance to our future. In search of a suitable drug target, Lipoteichoic acid Synthase (LtaS), an extracellular protein has been identified as a suitable candidate for a drug discovery campaign. Here, I describe our methodology for the identification and characterisation of small-molecule LtaS inhibitors that have been generated using a virtual screening approach. These compounds were able to act upon Gram-positive bacteria, such as methicillin-resistant Staphylococcus Aureus (MRSA), rendering them inactive and unable to survive.

This talk is part of the Darwin College Science Seminars series.

This talk is included in these lists:

• AUB_Cambridge Seminars
• All Talks (aka the CURE list)
• Centre for Health Leadership and Enterprise
• Chris Davis' list
• Darwin College Research Talks
• Darwin College Science Seminars
• Darwin Lectures and Seminars
• Guy Emerson's list
• Interested Talks
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• The Richard King Room, Darwin College
• custom

Note that ex-directory lists are not shown.