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Distinct tensile and adhesive forces determine germ layer organization during gastrulation
If you have a question about this talk, please contact Jurij Kotar.
Understanding the factors that produce tissue organization during development is one of the most fundamental goals in developmental biology. Various scenarios have been proposed in order to explain cell sorting and tissue organization on the basis of the differential properties and behaviors of the constituent cells. However, validating these scenarios has been notoriously difficult due to the lack of appropriate tools needed to simultaneously measure the relevant parameters. Here we show that by using a combination of single cell force spectroscopy, tissue culture and in vivo transplantation experiments, we are able to quantify the specific adhesive and mechanical properties of the different germ layer progenitors from gastrulating zebrafish embryos. With these values in hand, we propose a coherent scenario that accurately predicts germ layer organization during zebrafish gastrulation.
This talk is part of the BSS Formal Seminars series.
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