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Bioluminescent Reporter Screens: Illuminating Novel Regulators and Dynamics of Signaling Pathways

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Bioluminescent imaging (BLI) is a powerful noninvasive tool that has dramatically accelerated the in vivo interrogation of cancer systems and longitudinal analysis of mouse models of cancer over the past decade. Various luciferase enzymes have been genetically engineered into cells and mouse models of cancer, which permit investigation of cellular and molecular events associated with oncogenic transcription, posttranslational processing, protein–protein interactions, transformation, and oncogene addiction in live cells and animals. Luciferase-coupled reporters ultimately serve as a noninvasive, repetitive, longitudinal, and physiologic means by which cancer systems and therapeutic responses can be investigated accurately within the context of a living animal.

This talk is part of the BSS Formal Seminars series.

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