Molecular medicines for the lysosome

Add to your list(s) Download to your calendar using vCal

• Professor Timothy Cox MD FRCP FMedSci, Professor of Medicine Emeritus
• Monday 07 November 2016, 18:00-19:00
• Bristol-Myers Squibb Lecture Theatre, Department of Chemistry.

If you have a question about this talk, please contact Beverley Larner.

Abstract: This year saw the award of the third Nobel prize for research into the cell biology of the lysosome: an organelle for defence, recycling and energy-sensing of the metabolic economy.

Critical functions of lysosomes are revealed by the astonishing clinical diversity of genetic defects in this organelle – many of these rare diseases affect the brain. We are learning much about common conditions, such as myeloma and Parkinson disease, from their study.

Lysosomes may be accessed by proteins delivered at the cell surface and the spectacular success of macrophage-targeted enzyme therapy for Gaucher disease has stimulated development of inhibitors that rebalance defective lysosomal substrate recycling. The diseased brain remains a formidable challenge but gene therapy is promising and in early clinical development.

This talk is part of the Cambridge Philosophical Society series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biomimetic manufacturing and sustainability
• Bristol-Myers Squibb Lecture Theatre, Department of Chemistry
• Cambridge Philosophical Society
• Centre for Health Leadership and Enterprise
• Chris Davis' list
• Featured lists
• Featured talks
• Guy Emerson's list
• Major Public Lectures in Cambridge
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• PMRFPS's
• baz21 science lists
• custom
• ld636
• mig40's list
• personal list

Note that ex-directory lists are not shown.