University of Cambridge > > Biophysical Seminars > α-Synuclein: amyloid inclusions and supra-fibrillar structures

α-Synuclein: amyloid inclusions and supra-fibrillar structures

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Jerome Charmet.

Alpha-synuclein (aS) is a disordered membrane binding protein that plays a key role in the development of Parkinson’s disease (PD). In PD aS self-assembles into filamentous structures called amyloid fibrils. These fibrils are chemically and mechanically very stable. Once formed they cluster into characteristic cellular inclusions such as Lewy bodies. The forces driving inclusion body formation and their role in the disease pathology remain elusive. Lewy body formation has been associated with both neuroprotection and toxicity. In this talk, I will summarize our recent work on the accumulation aS in functionally different inclusions in cells and on the forces driving self-assembly of aS fibrils in supra-fibrillar structures in vitro. I will discuss how we used a broad repertoire of biophysical techniques to characterize aS amyloid micro- and nano-structures and obtain insight into possible disease mechanisms.

This talk is part of the Biophysical Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.


© 2006-2022, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity