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A V HILL LECTURE - Oxygen sensing: from worms to people and genes to drugs

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Abstract: We have used biochemical methods and genetic approaches in a variety of organisms ranging from worms to man to investigate how cells sense oxygen, and what they do in response to changes in its availability. This has uncovered a highly conserved pathway which operates in all metazoans. It is important in development, physiology and disease – perhaps most notably in cancer. The underlying oxygen sensing mechanism can be activated by small molecules which are now being tested as therapies for anaemia and ischaemic conditions.

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