University of Cambridge > Talks.cam > Biophysical Seminars > Naturally occurring micro reactors: phase separation as a regulated strategy for compartmentalisation in cells.

Naturally occurring micro reactors: phase separation as a regulated strategy for compartmentalisation in cells.

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Polymer theory predicts weakly interacting disordered proteins should phase separate. I’ll discuss some recent work where we demonstrate this phenomena with proteins, and show that this mechanism is used for organelle creation and cell compartmentalization in Eukaryotic cells. The interior of these bodies, which form reversibly and can be regulated with post translational modifications, amount to a solvent environment that is quite distinct from bulk water. Cells are effectively using the interior of these bodies as an alternative solvent to bulk water, much as an organic chemist would.

This talk is part of the Biophysical Seminars series.

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