University of Cambridge > Talks.cam > Biophysical Seminars > Looking at proteins in live cells with atomic resolution: From Science Fiction to Science Reality

Looking at proteins in live cells with atomic resolution: From Science Fiction to Science Reality

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Dr. Phil Selenko, will provide an update on his developments that enable in-cell aggregate characterisation. Hee will present recent progress in applying in-cell NMR and EPR methods to delineate full-scale atomic-resolution descriptions of the structure(s) and dynamics of the intrinsically disordered human amyloid protein alpha-synuclein in different mammalian cell types. Specifically, he will address whether specialized cells such as dopaminergic neurons promote the conversion of monomeric alpha-synuclein into folded helical tetramers as has been suggested recently. In that sense, ‘to fold or not to fold’ is the question that he intends to answer in this seminar.

This talk is part of the Biophysical Seminars series.

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