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Local Transcriptomes and proteomes in neurons

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Cajigas, I.J., Tushev, G., Will, T.J., tom Dieck, S., Fuerst, N., & Schuman. E.M. 2012. The Local Transcriptome in the Synaptic Neuropil Revealed by Deep Sequencing and High-Resolution Imaging. DOI 10 .1016/j.neuron.2012.02.036

Abstract. Nature Review Neuroscience 2013. Doi:10.1038/nrn3546 Proteostasis in complex dendrites. Hanus, C. & Schuman, E.M. Like all cells, neurons are made of proteins that have characteristic synthesis and degradation profiles. Unlike other cells, however, neurons have a unique multipolar architecture that makes ~10,000 synaptic contacts with other neurons. Both the stability and modifiability of the neuronal proteome are crucial for its information-processing, storage and plastic properties. The cell biological mechanisms that synthesize, modify, deliver and degrade dendritic and synaptic proteins are not well understood but appear to reflect unique solutions adapted to the particular morphology of neurons.

This talk is part of the Adrian Seminars in Neuroscience series.

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