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Protein misfolding and disaggregation by chaperones

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Professor Helen Saibil FRS is Bernal Professor of Structural Biology at Birkbeck, University of London.

Her group studies the operation of macromolecular machines using three-dimensional electron microscopy. Their research projects are in the areas of molecular chaperones and assisted protein folding/unfolding, misfolding into amyloid, and protein refolding in membrane pore formation. They use single particle cryo-electron microscopy and electron tomography to study isolated complexes, irregular assemblies and cell sections.

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This talk is part of the Cambridge University Biological Society series.

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