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Dissecting a protein-protein interaction in living cells
If you have a question about this talk, please contact Duncan Simpson.
Watching Living Matter
Proteins that sense and repair lesions in DNA maintain the integrity of the human genome during cell division, preventing the genetic instability that initiates diseases like cancer. These molecules work in multi-protein assemblies whose dynamic formation and dispersal underlies the reactions that lead to DNA repair, but how these protein-protein interactions are regulated is not well understood. In this talk, I will describe our work on the interaction between the breast cancer suppressor protein BRCA2 and its partner, the DNA repair enzyme RAD51 . We have combined methods from genetics, biochemistry and biophysics to describe how BRCA2 controls the availability and polymerization of RAD51 during the repair of double-strand DNA breaks in dividing cells.
This talk is part of the Physics of Living Matter PLM6 series.
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