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CATEGORIES:Physics of Living Matter PLM6
SUMMARY:Dissecting a protein-protein interaction in living
  cells - Professor Ashok Venkitaraman\, MRC Hutchi
 son Laboratory
DTSTART;TZID=Europe/London:20061117T100000
DTEND;TZID=Europe/London:20061117T103000
UID:TALK5312AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/5312
DESCRIPTION:Proteins that sense and repair lesions in DNA main
 tain the integrity of the human genome during cell
  division\, preventing the genetic instability tha
 t initiates diseases like cancer. These molecules 
 work in multi-protein assemblies whose dynamic for
 mation and dispersal underlies the reactions that 
 lead to DNA repair\, but how these protein-protein
  interactions are regulated is not well understood
 . In this talk\, I will describe our work on the i
 nteraction between the breast cancer suppressor pr
 otein BRCA2 and its partner\, the DNA repair enzym
 e RAD51. We have combined methods from genetics\, 
 biochemistry and biophysics to describe how BRCA2 
 controls the availability and polymerization of RA
 D51 during the repair of double-strand DNA breaks 
 in dividing cells.
LOCATION:Kaetsu Centre\, New Hall
CONTACT:Duncan Simpson
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