University of Cambridge > Talks.cam > Bradford Hill seminars at the Cambridge Institute of Public Health > Bacterial Genomes and Metagenomes: from point mutations to public health

Bacterial Genomes and Metagenomes: from point mutations to public health

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Lucy Lloyd.

Mark Pallen is a medically qualified bacteriologist with research interests that span genomics and bioinformatics and a spectrum of basic and applied research. He holds an undergraduate degree from Cambridge and a PhD from Imperial.

High-throughput sequencing (HT) has transformed clinical microbiology in recent years. Several proof-of-principle studies have shown that whole-genome sequencing, greatly facilitated by HTS , is able to provide a fine-grained view of the epidemiology of bacterial infections in the community and in hospitals, showing how pathogens and virulence/resistance spread and evolve. I will describe our experiences with this approach on Shiga-toxin-producing E. coli and the multi-drug resistant Gram-negative hospital pathogen, Acinetobacter baumannii. We have also been exploring the diagnostic potential of shotgun metagenomics—that is the open-ended sequencing of DNA from mixtures of organisms without culture or capture of bacterial cells. I will show how this approach can be used to recover genomes of E. coli and M. tuberculosis from clinical and historical samples, including retrospective diagnosis of tuberculosis in 18th Century Hungarian mummies.

This talk is part of the Bradford Hill seminars at the Cambridge Institute of Public Health series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

 

© 2006-2019 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity