University of Cambridge > Talks.cam > BSS Formal Seminars > Stochastic signal encoding strategies in single cells

  Browse A-Z

Log in

Cambridge users (raven)details Other usersdetails No account?details

Information on

Subscribing to talksdetails Finding a talkdetails Adding a talkdetails Disseminating talksdetails Help and Documentationdetails

Stochastic signal encoding strategies in single cells

Add to your list(s) Download to your calendar using vCal

If you have a question about this talk, please contact Alessio Zaccone.

Gene expression can be surprisingly dynamic and heterogeneous. This variability in gene expression, even in a clonal population of cells grown under the same condition, has been observed in diverse organisms, from mammalian stem cells to bacteria. It remains unclear how this variability is generated and what function it can serve.

We are using the B. subtilis general stress response regulator sigB as a model system to understand how heterogeneous cell states can be generated. By carrying out time-lapse microscopy of cells expressing a reporter of sigB activity, we discovered that sigB expression occurs in discrete pulses. The regulation of these pulses is input dependent. Energy stress causes sigB to be activated in continuous stochastic pulses. Environmental stress, however, results in a single pulse of sigB activation. By using a combination of mathematical modelling and synthetic biology techniques we were able to understand the mechanism of these two different dynamical regulation schemes. We are now testing the function and generality of pulsing as a regulatory strategy for the cell.

This talk is part of the BSS Formal Seminars series.

Tell a friend about this talk:

This talk is included in these lists:

Note that ex-directory lists are not shown.

Other lists

PMRFPS's Algebra and Representation Theory Seminar Art and Education Graduate Conference

Other talks

Why does cardiac function deteriorate in heart failure and how does phosphodiesterase 5 inhibition help? What You Don't Know About God Breckland, birds and conservation Decision Theory for AI safety Highly Energy Efficient Key-value Store for In-network Computing Gambling Disorder in the UK: an overview
 

© 2006-2021 Talks.cam, University of Cambridge. Contact Us | Help and Documentation | Privacy and Publicity