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Selection and clonal interference in a seasonal influenza virus

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Time-resolved genomic data provide a valuable insight into rapidly evolving populations. However, identifying the effects of selection from such data is not always straightforward, particularly where alleles at multiple genetic loci are simultaneously under selection. I describe a method for estimating the strength of selection acting at multiple polymorphic loci, and discuss its use to evaluate selection, and between-allele interference effects, in the evolution of the seasonal influenza virus H3N2 .

This talk is part of the Worms and Bugs series.

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