Models of the antibody response to malaria infection and vaccination in African children

Add to your list(s) Download to your calendar using vCal

• Michael White, Imperial
• Monday 21 November 2011, 11:30-12:30
• DD47, Cripps Court, Queens' College.

If you have a question about this talk, please contact Prof. Julia Gog.

Children in regions of intense malaria transmission are particularly vulnerable to malaria in their first years of life before they acquire substantial immunity. The processes underlying the acquisition and loss of immunity are investigated with biological models of immunological processes fitted to antibody titres to malaria parasite antigens using data from longitudinal cohort studies of Ghanaian and Gambian children.

Recent Phase III trials of the RTS ,S malaria vaccine have demonstrated 55% efficacy against clinical malaria in African children. Models are use to explore the potential impact of vaccination on naturally-acquired immunity and incidence of clinical malaria, in a range of transmission settings and against a background of existing malaria control interventions such as insecticide treated nets.

This talk is part of the Worms and Bugs series.

This talk is included in these lists:

• All CMS events
• All Talks (aka the CURE list)
• Cambridge Immunology
• Cambridge Infectious Diseases
• DD47, Cripps Court, Queens' College
• Worms and Bugs
• bld31

Note that ex-directory lists are not shown.