Autoantibodies against NMDA receptors and other neuronal targets: the widening spectrum of antibody-mediated CNS disorders

Add to your list(s) Download to your calendar using vCal

• Angela Vincent, University of Oxford
• Wednesday 22 June 2011, 14:30-16:15
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol.

If you have a question about this talk, please contact Scientific Meetings Co-ordinator.

Autoantibodies against the neuromuscular acetylcholine receptors in myasthenia gravis were first discovered almost 40 years ago, but the existence of autoantibodies that cause CNS disease has only recently been appreciated. Three main targets for the autoantibodies are components of the voltage-gated potassium channel complex, LGI1 and CASPR2 , and NMDA receptors. The diseases are usually quite sudden in onset with combinations of seizures, psychiatric and cognitive dysfunction, and the patients progress rapidly, unless treated with immunotherapies to reduce the levels of the antibodies, although some do improve spontaneously over time. Although, there are many questions outstanding, current knowledge of the cellular targets of the antibodies and the mechanisms involved will be discussed.

This talk is part of the MRC LMB Seminar Series series.

This talk is included in these lists:

• All Talks (aka the CURE list)
• Biology
• CCC talks for website
• Cambridge Immunology
• Centre for Health Leadership and Enterprise
• Liam
• Life Sciences
• Life Sciences
• ME Seminar
• MRC LMB Seminar Series
• Max Perutz Lecture Theatre, Medical Research Council (MRC) (MRC Laboratory of Molecular Biol
• Neurons, Fake News, DNA and your iPhone: The Mathematics of Information
• cri
• my_list
• other talks
• rc781

Note that ex-directory lists are not shown.