TODAY Adrian Seminar - "Physiological and genetic heterogeneity in hearing loss"

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• Karen Steel, King's College London
• Monday 05 March 2018, 16:30-18:00
• The Hodgkin Huxley Seminar Room, Department of Physiology Development and Neuroscience.

If you have a question about this talk, please contact Lyn Dakin.

Adult-onset hearing loss is very common but we know little about the underlying molecular pathogenesis, impeding development of therapies. We took a genetic approach to identify new molecules involved in hearing loss by screening a large cohort of newly-generated mouse mutants using auditory brainstem responses. This sensitive electrophysiological test revealed 38 unexpected genes associated with raised thresholds from our unbiased sample of 1,211 genes tested, suggesting extreme genetic heterogeneity with around 1,000 genes predicted to be involved in hearing impairment. Some mutant lines showed normal development followed by deterioration of responses, revealing new molecular pathways involved in progressive hearing loss. There was a wide range of pathophysiological mechanisms underlying the hearing loss. The new pathways required for maintenance of hearing discovered by this screen present new therapeutic opportunities, and both the data from the screen and the mouse mutants are available as a resource for further analysis.

This talk is part of the Adrian Seminars in Neuroscience series.

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