Intrinsically irregular spiking in a class of cortical inhibitory interneuron

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• Dr Hugh Robinson, Dept of Physiology, Development and Neuroscience, Univ of Cambridge
• Thursday 28 April 2011, 16:00-17:00
• Hodgkin Huxley Seminar Room, Physiology Building, Downing Site.

If you have a question about this talk, please contact Christian Scheppach.

Many neurons in the brain fire quite regularly or periodically when excited with a constant stimulus, and the ability to fire periodically is important for generating patterns of synchronous oscillation. Hodgkin-Huxley type models of voltage-dependent ionic conductances provide a good biophysical understanding of this behaviour. However, the dynamics of irregular or aperiodic firing in neurons is still poorly understood, and are complicated by the need to distinguish between the variability of the synaptic input and intrinsically-generated variability. I will describe our recent work on a novel type of irregular spiking (IS) inhibitory neuron in mammalian neocortex, in which the irregularity is generated intrinsically, and which can synchronise with other IS neurons via specific gap junctions. I will describe experiments on the properties and biophysical mechanisms of this irregularity, and propose a computational model which accounts for many of its features.

Joint work with Mariana Vargas-Caballero and Ole Paulsen.

This talk is part of the Foster Talks series.

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