|COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring.|
Intrinsically irregular spiking in a class of cortical inhibitory interneuron
If you have a question about this talk, please contact Christian Scheppach.
Many neurons in the brain fire quite regularly or periodically when excited with a constant stimulus, and the ability to fire periodically is important for generating patterns of synchronous oscillation. Hodgkin-Huxley type models of voltage-dependent ionic conductances provide a good biophysical understanding of this behaviour. However, the dynamics of irregular or aperiodic firing in neurons is still poorly understood, and are complicated by the need to distinguish between the variability of the synaptic input and intrinsically-generated variability. I will describe our recent work on a novel type of irregular spiking (IS) inhibitory neuron in mammalian neocortex, in which the irregularity is generated intrinsically, and which can synchronise with other IS neurons via specific gap junctions. I will describe experiments on the properties and biophysical mechanisms of this irregularity, and propose a computational model which accounts for many of its features.
Joint work with Mariana Vargas-Caballero and Ole Paulsen.
This talk is part of the Foster Talks series.
This talk is included in these lists:
Note that ex-directory lists are not shown.
Other listsPhysical Chemistry Research Interest Group Energy Innovation Beyond 2013: A talk by the Global Director of BP Ventures Monday Mechanics Seminars (DAMTP)
Other talksThe 2015 Obesity Summit “Light and colour: experiments and theory” Scalar Particles as Alternative-Sensitive Expressions Biology of Regenerative Medicines Conference Computing Assessing causality in perinatal and developmental epidemiology