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CATEGORIES:Foster Talks
SUMMARY:Intrinsically irregular spiking in a class of cort
 ical inhibitory interneuron - Dr Hugh Robinson\, D
 ept of Physiology\, Development and Neuroscience\,
  Univ of Cambridge
DTSTART;TZID=Europe/London:20110428T160000
DTEND;TZID=Europe/London:20110428T170000
UID:TALK31037AThttp://talks.cam.ac.uk
URL:http://talks.cam.ac.uk/talk/index/31037
DESCRIPTION:Many neurons in the brain fire quite regularly or 
 periodically when excited with a constant stimulus
 \, and the ability to fire periodically is importa
 nt for generating patterns of synchronous oscillat
 ion. Hodgkin-Huxley type models of voltage-depende
 nt ionic conductances provide a good biophysical u
 nderstanding of this behaviour.  However\, the dyn
 amics of irregular or aperiodic firing in neurons 
 is still poorly understood\, and are complicated b
 y the need to distinguish between the variability 
 of the synaptic input and intrinsically-generated 
 variability. I will describe our recent work on a 
 novel type of irregular spiking (IS) inhibitory ne
 uron in mammalian neocortex\, in which the irregul
 arity is generated intrinsically\, and which can s
 ynchronise with other IS neurons via specific gap 
 junctions.  I will describe experiments on the pro
 perties and biophysical mechanisms of this irregul
 arity\, and propose a computational model which ac
 counts for many of its features.\n\nJoint work wit
 h Mariana Vargas-Caballero and Ole Paulsen.\n
LOCATION:Hodgkin Huxley Seminar Room\, Physiology Building\
 , Downing Site
CONTACT:Christian Scheppach
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