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Structural insights into the initiation of DNA synthesis in eukaryotic replication

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If you have a question about this talk, please contact Dr Alfonso De Simone.

DNA polymerases need a primer to begin the synthesis of new DNA during replication. Nature has evolved specialised polymerases, termed primases, that are able to synthesise short RNA primers de novo. Because of the antiparallel nature of the DNA double helix, replication must start at least once on the leading strand and multiple times on the lagging strand. Thus, the enzymatic activity of the primase is constantly required at the replication fork. Our understanding of the molecular mechanisms by which primases synthesise the RNA primer is not well understood. In the talk, I will discuss our recent efforts to understand structure and function of the DNA Pol alpha/primase complex, responsible for initiation of DNA synthesis in eukaryotic replication.

This talk is part of the Biophysical Colloquia series.

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