Wires, Reporters and Information Capsules: Cellular journalism with DNA.

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• Dr. Yamuna Krishnan ( National Centre for Biological Sciences, Bangalore, India)
• Friday 19 February 2010, 14:00-15:00
• Pippard Lecture Theatre, Cavendish Laboratory.

If you have a question about this talk, please contact Erika Eiser.

DNA has attractive physicochemical characteristics such as robust thermal and hydrolytic stability. It also has desirable structural characteristics stemming from predictable and specific recognition properties that give rise to a highly regular helical structure which behaves as a rigid rod on length scales up to ~50 nm. Since these rigid rods may be welded together by complementary base-pairing, DNA is now taking on a new aspect where it is finding use as a construction element for architecture on the nanoscale. This field is called structural DNA nanotechnology. I describe approaches adopted by my lab where we demonstrate promising new self-assembly strategies that include the use of unusual forms of DNA in structural DNA nanotechnology to make molecular-scale devices. I will then go on to show the application of these DNA -based molecular devices in biological systems.

References: 1.Ghodke, H. B.; Krishnan, R.; Vignesh, K.; Kumar, G.V.P.; Narayana, C.; Krishnan, Y. (2007) The I-tetraplex building block: Rational Design and Controlled Fabrication of robust 1D DNA Scaffolds via non-Watson Crick self assembly. Angew. Chem. Int. Ed., 46, 2646-2649. 2. Bhatia, D., Mehtab, S., Krishnan, R., Indi, S.S., Basu, A., Krishnan, Y. (2009) Icosahedral DNA nanocapsules via modular assembly. Angew. Chem. Int. Ed. accepted. 3. Modi, S.; Swetha, M. G.; Goswami, D.; Gupta, G. D.; Mayor, S.; Krishnan, Y.* (2009) A DNA Nanomachine maps spatiotemporal pH in living cells. Nature Nanotechnology, 4, 325-330.

This talk is part of the BSS Formal Seminars series.

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