DNA-Encoded Chemical Libraries - A BIOLOGICAL RIG SEMINAR

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• Professor Dario Neri - CEO and CSO of Philogen, Professor of ETH Zürich, Honorary Senior Visiting Fellow, Department of Radiology, University of Cambridge (UK)
• Monday 31 March 2025, 15:00-16:00
• Department of Chemistry, Cambridge, Pfizer LT.

If you have a question about this talk, please contact Xani Thorman.

The discovery of small organic ligands, capable of specific recognition of protein targets of interest, is a central problem in Chemistry, Pharmacy, Biology and Medicine. Traditionally, small organic ligands to proteins are discovered by screening, one by one, individual compounds from chemical libraries. However, the technology is cumbersome, very expensive and is typically limited to the testing of up to one million compounds. DNA -encoded chemical library (DEL) technology allows the construction and screening of much larger compound libraries, without the need for expensive instrumentations and logistics. DELs are collections of molecules, individually coupled to distinctive DNA fragments, serving as amplifiable identification barcodes. Binding compounds can be selected using affinity capture procedures, with the protein target of interest immobilised on magnetic beads. After this “fishing” experiment, the DNA barcodes can be PCR amplified and quantified using high-throughput DNA sequencing [1]. In this lecture, I will present theory and applications of DEL technology. I will also show examples of DEL -derived ligands, isolated in our laboratories, which have been tested in patients with cancer, with promising clinical results.

This talk is part of the Biological Chemistry Research Interest Group series.

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