COOKIES: By using this website you agree that we can place Google Analytics Cookies on your device for performance monitoring. |
Cells Under the TipAdd to your list(s) Download to your calendar using vCal
If you have a question about this talk, please contact Erika Eiser. http://www.pellinglab.net/people.htm The mechanical properties of cells are becoming recognized as key indicators and control mechanisms during physiological processes such as mitosis, malignant transformations and differentiation. In addition, these properties are also highly responsive and time dependent. In this talk I will describe recent work utilizing simultaneous atomic force microscopy, traction force microscopy and laser scanning confocal microscopy to investigate dynamic and timescale dependent cell mechanics. In combination with modern molecular biology and physical/computational approaches we examined the transmission of force through living cells resulting in dynamic remodeling of focal adhesions and viscous three-dimensional relaxation of the cytoskeleton. In turn, the mechanical response of the cell was also observed to be highly regulated by the substrate stiffness. These approaches were then applied to study the programmed mechanical breakdown of the cell during early apoptosis (cell death). Cytoskeletal control of short ( 1min) term elastic and viscous deformations were quantified and directly linked to the cell death program in a time-dependent manner. Cell mechanics is distinctly controlled by time and cell-type dependent mechanisms which, in turn, are governed by the mechanical micro-environment. The interesting physics is not merely a side-product of biology but is a key component of a biological and physical feedback loop governing the life of a cell. This talk is part of the BSS Formal Seminars series. This talk is included in these lists:
Note that ex-directory lists are not shown. |
Other listsGerman Society Speaker Events Wildlife and Environment Cambridge Oceanography GroupOther talksFields of definition of Fukaya categories of Calabi-Yau hypersurfaces The statistical model of nuclear fission: from Bohr-Wheeler to heavy-ion fusion-fission reactions Brest-Litovsk and the Making of Modern Ukraine and Russia Childhood adversity and chronic disease: risks, mechanisms and resilience. TODAY Adrian Seminar: "Starting new actions and learning from it" Beating your final boss battle, or presenting with confidence and style (easy mode) The Global Warming Sceptic Dynamics of Phenotypic and Genomic Evolution in a Long-Term Experiment with E. coli Statistical Methods in Pre- and Clinical Drug Development: Tumour Growth-Inhibition Model Example Art and Migration Cambridge-Lausanne Workshop 2018 - Day 2 Roland the Hero |